This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1sz9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1sz9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1sz9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1sz9| PDB=1sz9 | SCENE= }}
{{STRUCTURE_1sz9| PDB=1sz9 | SCENE= }}
-
'''The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model'''
+
===The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model===
-
==Overview==
+
<!--
-
During transcription, RNA polymerase (Pol) II synthesizes eukaryotic messenger RNA. Transcription is coupled to RNA processing by the carboxy-terminal domain (CTD) of Pol II, which consists of up to 52 repeats of the sequence Tyr 1-Ser 2-Pro 3-Thr 4-Ser 5-Pro 6-Ser 7 (refs 1, 2). After phosphorylation, the CTD binds tightly to a conserved CTD-interacting domain (CID) present in the proteins Pcf11 and Nrd1, which are essential and evolutionarily conserved factors for polyadenylation-dependent and -independent 3'-RNA processing, respectively. Here we describe the structure of a Ser 2-phosphorylated CTD peptide bound to the CID domain of Pcf11. The CTD motif Ser 2-Pro 3-Thr 4-Ser 5 forms a beta-turn that binds to a conserved groove in the CID domain. The Ser 2 phosphate group does not make direct contact with the CID domain, but may be recognized indirectly because it stabilizes the beta-turn with an additional hydrogen bond. Iteration of the peptide structure results in a compact beta-spiral model of the CTD. The model suggests that, during the mRNA transcription-processing cycle, compact spiral regions in the CTD are unravelled and regenerated in a phosphorylation-dependent manner.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15241417}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15241417 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15241417}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Pcf11]]
[[Category: Pcf11]]
[[Category: Rna polymerase ii ctd interacting domain]]
[[Category: Rna polymerase ii ctd interacting domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:18:16 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:38:54 2008''

Revision as of 07:38, 28 July 2008

Image:1sz9.png

Template:STRUCTURE 1sz9

The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model

Template:ABSTRACT PUBMED 15241417

About this Structure

1SZ9 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors., Meinhart A, Cramer P, Nature. 2004 Jul 8;430(6996):223-6. PMID:15241417

Page seeded by OCA on Mon Jul 28 10:38:54 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sz9"
Personal tools