This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1szh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1szh.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1szh.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1szh| PDB=1szh | SCENE= }}
{{STRUCTURE_1szh| PDB=1szh | SCENE= }}
-
'''Crystal Structure of C. elegans HER-1'''
+
===Crystal Structure of C. elegans HER-1===
-
==Overview==
+
<!--
-
HER-1 is a secreted protein that promotes male development in the nematode Caenorhabditis elegans. HER-1 inhibits the function of TRA-2A, a multipass integral membrane protein thought to serve as its receptor. We report here the 1.5-A crystal structure of HER-1. The structure was solved by the multiwavelength anomalous diffraction method by using selenomethionyl-substituted HER-1 produced in Chinese hamster ovary cells. The HER-1 structure consists of two all-helical domains and is not closely homologous to any known structure. Sites of amino acid substitutions known to impair HER-1 function were mapped on the HER-1 structure and classified according to the likely mechanism by which they affect HER-1 activity. A subset of these and other amino acid substitutions on the HER-1 surface were assayed for their ability to disrupt interactions between HER-1 and TRA-2A-expressing cells, and a localized region on the HER-1 surface important for mediating this interaction was identified.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15289613}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15289613 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15289613}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Left-handed anti-parallel 4-helix bundle]]
[[Category: Left-handed anti-parallel 4-helix bundle]]
[[Category: Overhand 3-helix bundle]]
[[Category: Overhand 3-helix bundle]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:18:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:24:28 2008''

Revision as of 03:24, 28 July 2008

Image:1szh.png

Template:STRUCTURE 1szh

Crystal Structure of C. elegans HER-1

Template:ABSTRACT PUBMED 15289613

About this Structure

1SZH is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A., Hamaoka BY, Dann CE 3rd, Geisbrecht BV, Leahy DJ, Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11673-8. Epub 2004 Aug 2. PMID:15289613

Page seeded by OCA on Mon Jul 28 06:24:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1szh"
Personal tools