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1szt

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{{STRUCTURE_1szt| PDB=1szt | SCENE= }}
{{STRUCTURE_1szt| PDB=1szt | SCENE= }}
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'''ATOMIC STRUCTURE OF A THERMOSTABLE SUBDOMAIN OF HIV-1 GP41'''
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===ATOMIC STRUCTURE OF A THERMOSTABLE SUBDOMAIN OF HIV-1 GP41===
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==Overview==
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Infection by HIV-1 involves the fusion of viral and cellular membranes with subsequent transfer of viral genetic material into the cell. The HIV-1 envelope glycoprotein that mediates fusion consists of the surface subunit gp120 and the transmembrane subunit gp41. gp120 directs virion attachment to the cell-surface receptors, and gp41 then promotes viral-cell membrane fusion. A soluble, alpha-helical, trimeric complex within gp41 composed of N-terminal and C-terminal extraviral segments has been proposed to represent the core of the fusion-active conformation of the HIV-1 envelope. A thermostable subdomain denoted N34(L6)C28 can be formed by the N-34 and C-28 peptides connected by a flexible linker in place of the disulfide-bonded loop region. Three-dimensional structure of N34(L6)C28 reveals that three molecules fold into a six-stranded helical bundle. Three N-terminal helices within the bundle form a central, parallel, trimeric coiled coil, whereas three C-terminal helices pack in the reverse direction into three hydrophobic grooves on the surface of the N-terminal trimer. This thermostable subdomain displays the salient features of the core structure of the isolated gp41 subunit and thus provides a possible target for therapeutics designed selectively to block HIV-1 entry.
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(as it appears on PubMed at http://www.pubmed.gov), where 9356444 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9356444}}
==About this Structure==
==About this Structure==
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[[Category: Coat protein]]
[[Category: Coat protein]]
[[Category: Hiv-1 envelope glycoprotein]]
[[Category: Hiv-1 envelope glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:19:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:31:48 2008''

Revision as of 12:31, 29 July 2008

Image:1szt.png

Template:STRUCTURE 1szt

ATOMIC STRUCTURE OF A THERMOSTABLE SUBDOMAIN OF HIV-1 GP41

Template:ABSTRACT PUBMED 9356444

About this Structure

1SZT is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Atomic structure of a thermostable subdomain of HIV-1 gp41., Tan K, Liu J, Wang J, Shen S, Lu M, Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12303-8. PMID:9356444

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