1t01

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{{STRUCTURE_1t01| PDB=1t01 | SCENE= }}
{{STRUCTURE_1t01| PDB=1t01 | SCENE= }}
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'''Vinculin complexed with the VBS1 helix from talin'''
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===Vinculin complexed with the VBS1 helix from talin===
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==Overview==
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The interaction between the cytoskeletal proteins talin and vinculin plays a key role in integrin-mediated cell adhesion and migration. We have determined the crystal structures of two domains from the talin rod spanning residues 482-789. Talin 482-655, which contains a vinculin-binding site (VBS), folds into a five-helix bundle whereas talin 656-789 is a four-helix bundle. We show that the VBS is composed of a hydrophobic surface spanning five turns of helix 4. All the key side chains from the VBS are buried and contribute to the hydrophobic core of the talin 482-655 fold. We demonstrate that the talin 482-655 five-helix bundle represents an inactive conformation, and mutations that disrupt the hydrophobic core or deletion of helix 5 are required to induce an active conformation in which the VBS is exposed. We also report the crystal structure of the N-terminal vinculin head domain in complex with an activated form of talin. Activation of the VBS in talin and the recruitment of vinculin may support the maturation of small integrin/talin complexes into more stable adhesions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15272303 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15272303}}
==About this Structure==
==About this Structure==
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[[Category: Papagrigoriou, E.]]
[[Category: Papagrigoriou, E.]]
[[Category: Five helix bundle]]
[[Category: Five helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:20:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:17:40 2008''

Revision as of 17:17, 27 July 2008

Image:1t01.png

Template:STRUCTURE 1t01

Vinculin complexed with the VBS1 helix from talin

Template:ABSTRACT PUBMED 15272303

About this Structure

1T01 is a Protein complex structure of sequences from Gallus gallus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle., Papagrigoriou E, Gingras AR, Barsukov IL, Bate N, Fillingham IJ, Patel B, Frank R, Ziegler WH, Roberts GC, Critchley DR, Emsley J, EMBO J. 2004 Aug 4;23(15):2942-51. Epub 2004 Jul 22. PMID:15272303

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