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1t0k

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{{STRUCTURE_1t0k| PDB=1t0k | SCENE= }}
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'''Joint X-ray and NMR Refinement of Yeast L30e-mRNA complex'''
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===Joint X-ray and NMR Refinement of Yeast L30e-mRNA complex===
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==Overview==
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L30e, a Saccharomyces cervisiae ribosomal protein, regulates its own expression by binding to a purine-rich asymmetric internal loop located in both its pre-mRNA and mature mRNA. A crystal structure of an MBP-L30e fusion protein in complex with an RNA containing the pre-mRNA regulatory site was solved at 3.24 A. Interestingly, the structure of the RNA differed from that observed in a previously determined NMR structure of the complex. Analysis of the NMR data led to the identification of a single imino proton resonance in the internal loop that had been incorrectly assigned and was principally responsible for the erroneous RNA structure. A structure refinement was performed using both the X-ray diffraction data and the NMR-derived distance and angle restraints. The joint NMR and X-ray refinement resulted in improved stereochemistry and lower crystallographic R factors. The RNA internal loop of the MBP-L30e-mRNA complex adopts the canonical K-turn fold.
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(as it appears on PubMed at http://www.pubmed.gov), where 15242593 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15242593}}
==About this Structure==
==About this Structure==
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[[Category: Mbp fusion protein]]
[[Category: Mbp fusion protein]]
[[Category: Ribosomal protein l30e]]
[[Category: Ribosomal protein l30e]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:21:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:47:48 2008''

Revision as of 04:47, 29 July 2008

Image:1t0k.png

Template:STRUCTURE 1t0k

Joint X-ray and NMR Refinement of Yeast L30e-mRNA complex

Template:ABSTRACT PUBMED 15242593

About this Structure

1T0K is a Protein complex structure of sequences from Escherichia coli and Saccharomyces cerevisiae. This structure supersedes the now removed PDB entries and 1cn9. Full crystallographic information is available from OCA.

Reference

Joint X-ray and NMR refinement of the yeast L30e-mRNA complex., Chao JA, Williamson JR, Structure. 2004 Jul;12(7):1165-76. PMID:15242593

Page seeded by OCA on Tue Jul 29 07:47:48 2008

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