1t11

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[[Image:1t11.gif|left|200px]]
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{{STRUCTURE_1t11| PDB=1t11 | SCENE= }}
{{STRUCTURE_1t11| PDB=1t11 | SCENE= }}
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'''Trigger Factor'''
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===Trigger Factor===
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==Overview==
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Trigger factor is a molecular chaperone that is present in all species of eubacteria. It binds to the ribosomal 50S subunit near the translation exit tunnel and is thought to be the first protein to interact with nascent polypeptides emerging from the ribosome. The chaperone has a peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the rate-limiting proline isomerization in the protein-folding process. We have determined the crystal structure of nearly full-length trigger factor from Vibrio cholerae by x-ray crystallography at 2.5-A resolution. The structure is composed of two trigger-factor molecules related by a noncrystallographic two-fold symmetry axis. The monomer has an elongated shape and is folded into three domains: an N-terminal domain I that binds to the ribosome, a central domain II that contains PPIase activity, and a C-terminal domain III. The active site of the PPIase domain is occupied by a loop from domain III, suggesting that the PPIase activity of the protein could be regulated. The dimer interface is formed between domains I and III and contains residues of mixed properties. Further implications about dimerization, ribosome binding, and other functions of trigger factor are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15353602 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15353602}}
==About this Structure==
==About this Structure==
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[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
[[Category: Ppiase]]
[[Category: Ppiase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:22:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:01:51 2008''

Revision as of 21:01, 28 July 2008

Image:1t11.png

Template:STRUCTURE 1t11

Trigger Factor

Template:ABSTRACT PUBMED 15353602

About this Structure

1T11 is a Single protein structure of sequence from Vibrio cholerae. Full crystallographic information is available from OCA.

Reference

The crystal structure of ribosomal chaperone trigger factor from Vibrio cholerae., Ludlam AV, Moore BA, Xu Z, Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13436-41. Epub 2004 Sep 7. PMID:15353602

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