1t1a

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{{STRUCTURE_1t1a| PDB=1t1a | SCENE= }}
{{STRUCTURE_1t1a| PDB=1t1a | SCENE= }}
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'''Late intermediate IL1 from time-resolved crystallography of the E46Q mutant of PYP'''
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===Late intermediate IL1 from time-resolved crystallography of the E46Q mutant of PYP===
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==Overview==
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In the bacterial photoreceptor photoactive yellow protein (PYP), absorption of blue light by its chromophore leads to a conformational change in the protein associated with differential signaling activity, as it executes a reversible photocycle. Time-resolved Laue crystallography allows structural snapshots (as short as 150 ps) of high crystallographic resolution (approximately 1.6 A) to be taken of a protein as it functions. Here, we analyze by singular value decomposition a comprehensive time-resolved crystallographic data set of the E46Q mutant of PYP throughout the photocycle spanning 10 ns-100 ms. We identify and refine the structures of five distinct intermediates and provide a plausible chemical kinetic mechanism for their inter conversion. A clear structural progression is visible in these intermediates, in which a signal generated at the chromophore propagates through a distinct structural pathway of conserved residues and results in structural changes near the N terminus, over 20 A distant from the chromophore.
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(as it appears on PubMed at http://www.pubmed.gov), where 15642261 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15642261}}
==About this Structure==
==About this Structure==
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[[Category: Pas domain]]
[[Category: Pas domain]]
[[Category: Photoactive yellow protein]]
[[Category: Photoactive yellow protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:22:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:38:29 2008''

Revision as of 09:38, 10 July 2008

Image:1t1a.png

Template:STRUCTURE 1t1a

Late intermediate IL1 from time-resolved crystallography of the E46Q mutant of PYP

Template:ABSTRACT PUBMED 15642261

About this Structure

1T1A is a Single protein structure of sequence from Halorhodospira halophila. Full crystallographic information is available from OCA.

Reference

A structural pathway for signaling in the E46Q mutant of photoactive yellow protein., Rajagopal S, Anderson S, Srajer V, Schmidt M, Pahl R, Moffat K, Structure. 2005 Jan;13(1):55-63. PMID:15642261

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