Journal:Acta Cryst D:S2059798324005461

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Evaluation of 189 structures of ASNases that were present in the PDB as of November 2023 was described in Wlodawer et al. (2024)</ref><ref name="dependable"/>. Most structures did not raise any significant concerns. However, 30 models had various kinds of stereochemical problems and/or doubtful agreement with the experimental electron density maps. Consequently, they were re-refined in order to remove the shortcomings. An example can be seen in the high resolution structure of Elspar, where the electron density maps clearly indicated substitutions, ''e.g.'', '''V27A''' and '''S252T'''.
Evaluation of 189 structures of ASNases that were present in the PDB as of November 2023 was described in Wlodawer et al. (2024)</ref><ref name="dependable"/>. Most structures did not raise any significant concerns. However, 30 models had various kinds of stereochemical problems and/or doubtful agreement with the experimental electron density maps. Consequently, they were re-refined in order to remove the shortcomings. An example can be seen in the high resolution structure of Elspar, where the electron density maps clearly indicated substitutions, ''e.g.'', '''V27A''' and '''S252T'''.
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[[Image:Fig 04a New 10 mesh p8 25pc 425x253.gif|frame|left|Substitution of V27A in the more dependable structure of [[1nns]]. 2Fo-Fc contoured at 1σ in black, and Fo-Fc at -3σ in red and Fo-Fc at 3σ in green.]]
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[[Image:Fig_04b_New_10_mesh_p8_25pc_425x253.gif|frame|left|Substitution of S252T in the more dependable structure of [[1nns]]. 2Fo-Fc contoured at 1σ in black, and Fo-Fc at -3σ in red and Fo-Fc at 3σ in green.]]
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{|
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|-
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!V27A
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!S252T
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|-
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|[[Image:Fig 04a New 10 mesh p8 25pc 425x253.gif|425px]]
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|[[Image:Fig_04b_New_10_mesh_p8_25pc_425x253.gif|425px]]
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|}
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Substitution of V27A in the more dependable structure of [[1nns]]. 2Fo-Fc contoured at 1σ in black, and Fo-Fc at -3σ in red and Fo-Fc at 3σ in green.]]
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Substitution of S252T in the more dependable structure of [[1nns]]. 2Fo-Fc contoured at 1σ in black, and Fo-Fc at -3σ in red and Fo-Fc at 3σ in green.]]
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The revised models (listed here) may be downloaded from this site in both the legacy PDB and mmCIF formats.
The revised models (listed here) may be downloaded from this site in both the legacy PDB and mmCIF formats.

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