1t2s

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[[Image:1t2s.gif|left|200px]]
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{{Seed}}
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[[Image:1t2s.png|left|200px]]
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{{STRUCTURE_1t2s| PDB=1t2s | SCENE= }}
{{STRUCTURE_1t2s| PDB=1t2s | SCENE= }}
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'''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain'''
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===Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain===
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==Overview==
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We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.
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(as it appears on PubMed at http://www.pubmed.gov), where 15156196 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15156196}}
==About this Structure==
==About this Structure==
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1T2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2S OCA].
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1T2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2S OCA].
==Reference==
==Reference==
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[[Category: Dna]]
[[Category: Dna]]
[[Category: Nucleic acid binding protein]]
[[Category: Nucleic acid binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:26:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:54:48 2008''

Revision as of 15:54, 28 July 2008

Image:1t2s.png

Template:STRUCTURE 1t2s

Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain

Template:ABSTRACT PUBMED 15156196

About this Structure

1T2S is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196

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