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1t5e

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[[Image:1t5e.gif|left|200px]]
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{{STRUCTURE_1t5e| PDB=1t5e | SCENE= }}
{{STRUCTURE_1t5e| PDB=1t5e | SCENE= }}
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'''The structure of MexA'''
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===The structure of MexA===
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==Overview==
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Multidrug resistance among Gram-negative bacteria is conferred by three-component membrane pumps that expel diverse antibiotics from the cell. These efflux pumps consist of an inner membrane transporter such as the AcrB proton antiporter, an outer membrane exit duct of the TolC family, and a periplasmic protein known as the adaptor. We present the x-ray structure of the MexA adaptor from the human pathogen Pseudomonas aeruginosa. The elongated molecule contains three linearly arranged subdomains; a 47-A-long alpha-helical hairpin, a lipoyl domain, and a six-stranded beta-barrel. In the crystal, hairpins of neighboring MexA monomers pack side-by-side to form twisted arcs. We discuss the implications of the packing of molecules within the crystal. On the basis of the structure and packing, we suggest a model for the key periplasmic interaction between the outer membrane channel and the adaptor protein in the assembled drug efflux pump.
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(as it appears on PubMed at http://www.pubmed.gov), where 15226509 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15226509}}
==About this Structure==
==About this Structure==
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[[Category: Mexa]]
[[Category: Mexa]]
[[Category: Periplasmic adaptor protein]]
[[Category: Periplasmic adaptor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:32:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:25:24 2008''

Revision as of 13:25, 29 July 2008

Image:1t5e.png

Template:STRUCTURE 1t5e

The structure of MexA

Template:ABSTRACT PUBMED 15226509

About this Structure

1T5E is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structure of the periplasmic component of a bacterial drug efflux pump., Higgins MK, Bokma E, Koronakis E, Hughes C, Koronakis V, Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):9994-9. Epub 2004 Jun 28. PMID:15226509

Page seeded by OCA on Tue Jul 29 16:25:24 2008

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