1wwb
From Proteopedia
(New page: 200px<br /> <applet load="1wwb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wwb, resolution 2.1Å" /> '''LIGAND BINDING DOMAI...) |
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caption="1wwb, resolution 2.1Å" /> | caption="1wwb, resolution 2.1Å" /> | ||
'''LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR'''<br /> | '''LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1WWB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1WWB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: trk receptor]] | [[Category: trk receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:08:02 2008'' |
Revision as of 15:08, 15 February 2008
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LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR
Contents |
Overview
The Trk receptors and their neurotrophin ligands control development and, maintenance of the nervous system. The crystal structures of the ligand, binding domain of TrkA, TrkB, and TrkC were solved and refined to high, resolution. The domains adopt an immunoglobulin-like fold, but, crystallized in all three instances as dimers with the N-terminal strand, of each molecule replaced by the same strand of a symmetry-related mate., Models of the correctly folded domains could be constructed by changing, the position of a single residue, and the resulting model of the binding, domain of TrkA is essentially identical with the bound structure as, observed in a complex with nerve growth factor. An analysis of the, existing mutagenesis data for TrkA and TrkC in light of these structures, reveals the structural reasons for the specificity among the Trk, receptors, and explains the underpinnings of the multi-functional ligands, that have been reported. The overall structure of all three domains, belongs to the I-set of immunoglobulin-like domains, but shows several, unusual features, such as an exposed disulfide bridge linking two, neighboring strands in the same beta-sheet. For all three domains, the, residues that deviate from the standard fingerprint pattern common to the, I-set family fall in the region of the ligand binding site observed in the, complex. Therefore, identification of these deviations in the sequences of, other immunoglobulin-like domain-containing receptors may help to identify, their ligand binding site even in the absence of structural or mutagenesis, data.
Disease
Known diseases associated with this structure: Obesity, hyperphagia, and developmental delay OMIM:[600456]
About this Structure
1WWB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC., Ultsch MH, Wiesmann C, Simmons LC, Henrich J, Yang M, Reilly D, Bass SH, de Vos AM, J Mol Biol. 1999 Jul 2;290(1):149-59. PMID:10388563
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