1t5t

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[[Image:1t5t.gif|left|200px]]
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{{Seed}}
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[[Image:1t5t.png|left|200px]]
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{{STRUCTURE_1t5t| PDB=1t5t | SCENE= }}
{{STRUCTURE_1t5t| PDB=1t5t | SCENE= }}
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'''Structure of the (SR)Ca2+-ATPase Ca2-E1-ADP:AlF4- form'''
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===Structure of the (SR)Ca2+-ATPase Ca2-E1-ADP:AlF4- form===
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==Overview==
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A tight coupling between adenosine triphosphate (ATP) hydrolysis and vectorial ion transport has to be maintained by ATP-consuming ion pumps. We report two crystal structures of Ca2+-bound sarco(endo)plasmic reticulum Ca2+-adenosine triphosphatase (SERCA) at 2.6 and 2.9 angstrom resolution in complex with (i) a nonhydrolyzable ATP analog [adenosine (beta-gamma methylene)-triphosphate] and (ii) adenosine diphosphate plus aluminum fluoride. SERCA reacts with ATP by an associative mechanism mediated by two Mg2+ ions to form an aspartyl-phosphorylated intermediate state (Ca2-E1 approximately P). The conformational changes that accompany the reaction with ATP pull the transmembrane helices 1 and 2 and close a cytosolic entrance for Ca2+, thereby preventing backflow before Ca2+ is released on the other side of the membrane.
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The line below this paragraph, {{ABSTRACT_PUBMED_15192230}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15192230 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15192230}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Transition state]]
[[Category: Transition state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:33:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:54:57 2008''

Revision as of 13:55, 27 July 2008

Image:1t5t.png

Template:STRUCTURE 1t5t

Structure of the (SR)Ca2+-ATPase Ca2-E1-ADP:AlF4- form

Template:ABSTRACT PUBMED 15192230

About this Structure

1T5T is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Phosphoryl transfer and calcium ion occlusion in the calcium pump., Sorensen TL, Moller JV, Nissen P, Science. 2004 Jun 11;304(5677):1672-5. PMID:15192230

Page seeded by OCA on Sun Jul 27 16:54:57 2008

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