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1t6l

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{{STRUCTURE_1t6l| PDB=1t6l | SCENE= }}
{{STRUCTURE_1t6l| PDB=1t6l | SCENE= }}
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'''Crystal Structure of the Human Cytomegalovirus DNA Polymerase Subunit, UL44'''
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===Crystal Structure of the Human Cytomegalovirus DNA Polymerase Subunit, UL44===
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==Overview==
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The human cytomegalovirus DNA polymerase consists of a catalytic subunit, UL54, and a presumed processivity factor, UL44. We have solved the crystal structure of residues 1-290 of UL44 to 1.85 A resolution by multiwavelength anomalous dispersion. The structure reveals a dimer of UL44 in the shape of a C clamp. Each monomer of UL44 shares its overall fold with other processivity factors, including herpes simplex virus UL42, which is a monomer that binds DNA directly, and the sliding clamp, PCNA, which is a trimer that surrounds DNA, although these proteins share no obvious sequence homology. Analytical ultracentrifugation and gel filtration measurements demonstrated that UL44 also forms a dimer in solution, and substitution of large hydrophobic residues along the homodimer interface with alanine disrupted dimerization and decreased DNA binding. UL44 represents a hybrid processivity factor as it binds DNA directly like UL42, but forms a C clamp that may surround DNA like PCNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 15260974 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15260974}}
==About this Structure==
==About this Structure==
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[[Category: Loregian, A.]]
[[Category: Loregian, A.]]
[[Category: Processivity fold]]
[[Category: Processivity fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:35:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:04:39 2008''

Revision as of 05:04, 28 July 2008

Image:1t6l.png

Template:STRUCTURE 1t6l

Crystal Structure of the Human Cytomegalovirus DNA Polymerase Subunit, UL44

Template:ABSTRACT PUBMED 15260974

About this Structure

1T6L is a Single protein structure of sequence from Human herpesvirus 5. Full crystallographic information is available from OCA.

Reference

The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer., Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM, Mol Cell. 2004 Jul 23;15(2):233-44. PMID:15260974

Page seeded by OCA on Mon Jul 28 08:04:39 2008

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