9gkq

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Current revision (04:06, 14 September 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9gkq is ON HOLD until 2026-08-26
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==Cryo-EM structure of Botulinum neurotoxin serotype A==
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<StructureSection load='9gkq' size='340' side='right'caption='[[9gkq]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9gkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GKQ FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gkq OCA], [https://pdbe.org/9gkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gkq RCSB], [https://www.ebi.ac.uk/pdbsum/9gkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gkq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BXA1_CLOBH BXA1_CLOBH] Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
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__TOC__
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</StructureSection>
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[[Category: Clostridium botulinum]]
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[[Category: Large Structures]]
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[[Category: He J]]
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[[Category: Lei D]]
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[[Category: Liu Z]]
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[[Category: Qi F]]
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[[Category: Wang D]]
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[[Category: Wang X]]
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[[Category: Zerang Z]]
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[[Category: Zhi D]]

Current revision

Cryo-EM structure of Botulinum neurotoxin serotype A

PDB ID 9gkq

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OCA

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