9iyz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the Acinetobacter baumannii LysR family regulator AceR DNA-binding domain (P321)== | |
| - | + | <StructureSection load='9iyz' size='340' side='right'caption='[[9iyz]], [[Resolution|resolution]] 1.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9iyz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_ATCC_17978 Acinetobacter baumannii ATCC 17978]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IYZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9iyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9iyz OCA], [https://pdbe.org/9iyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9iyz RCSB], [https://www.ebi.ac.uk/pdbsum/9iyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9iyz ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACER_ACIBT ACER_ACIBT] Regulates the expression of the AceI transporter (PubMed:29481596). Binds DNA and chlorhexidine (PubMed:29481596, PubMed:32636271). Binds to regulatory sites within the intergenic region between the aceI and aceR genes, and affects the interaction between RNA polymerase (RNAP) and promoter DNA both in the presence and in the absence of chlorhexidine (PubMed:29481596, PubMed:32636271). In the absence of chlorhexidine, prevents transcription of the aceI gene by disrupting interactions between the promoter DNA and RNAP (PubMed:32636271). In the presence of chlorhexidine, activates expression of aceI (PubMed:29481596, PubMed:32636271). When AceR interacts with chlorhexidine, it undergoes a conformational change and the tetrameric form either releases the DNA or shifts the position of the DNA-binding region to allow RNAP to bind onto the promoter DNA to proceed with aceI transcription (PubMed:32636271).<ref>PMID:29481596</ref> <ref>PMID:32636271</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Acinetobacter baumannii ATCC 17978]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ge HH]] | ||
| + | [[Category: Ma JM]] | ||
| + | [[Category: Wang N]] | ||
Current revision
Crystal Structure of the Acinetobacter baumannii LysR family regulator AceR DNA-binding domain (P321)
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