1t6v

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[[Image:1t6v.gif|left|200px]]
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{{STRUCTURE_1t6v| PDB=1t6v | SCENE= }}
{{STRUCTURE_1t6v| PDB=1t6v | SCENE= }}
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'''Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme'''
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===Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme===
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==Overview==
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Cartilaginous fish are the phylogenetically oldest living organisms known to possess components of the vertebrate adaptive immune system. Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V domains. The 1.45 angstrom resolution crystal structure of the type I IgNAR V domain in complex with hen egg-white lysozyme (HEL) reveals a minimal antigen-binding domain that contains only two of the three conventional complementarity-determining regions but still binds HEL with nanomolar affinity by means of a binding interface comparable in size to conventional antibodies.
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The line below this paragraph, {{ABSTRACT_PUBMED_15319492}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15319492 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15319492}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:36:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:10:18 2008''

Revision as of 14:10, 27 July 2008

Image:1t6v.png

Template:STRUCTURE 1t6v

Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme

Template:ABSTRACT PUBMED 15319492

About this Structure

1T6V is a Protein complex structure of sequences from Gallus gallus and Ginglymostoma cirratum. Full crystallographic information is available from OCA.

Reference

Crystal structure of a shark single-domain antibody V region in complex with lysozyme., Stanfield RL, Dooley H, Flajnik MF, Wilson IA, Science. 2004 Sep 17;305(5691):1770-3. Epub 2004 Aug 19. PMID:15319492

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