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1t8t

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{{STRUCTURE_1t8t| PDB=1t8t | SCENE= }}
{{STRUCTURE_1t8t| PDB=1t8t | SCENE= }}
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'''Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP'''
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===Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP===
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==Overview==
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Heparan sulfate (HS) plays essential roles in assisting herpes simplex virus infection and other biological processes. The biosynthesis of HS includes numerous specialized sulfotransferases that generate a variety of sulfated saccharide sequences, conferring the selectivity of biological functions of HS. We report a structural study of human HS 3-O-sulfotransferase isoform 3 (3-OST-3), a key sulfotransferase that transfers a sulfuryl group to a specific glucosamine in HS generating an entry receptor for herpes simplex virus 1. We have obtained the crystal structure of 3-OST-3 at 1.95 A in a ternary complex with 3'-phosphoadenosine 5'-phosphate and a tetrasaccharide substrate. Mutational analyses were also performed on the residues involved in the binding of the substrate. Residues Gln255 and Lys368 are essential for the sulfotransferase activity and lie within hydrogen bonding distances to the carboxyl and sulfo groups of the uronic acid unit. These residues participate in the substrate recognition of 3-OST-3. This structure provides atomic level evidence for delineating the substrate recognition and catalytic mechanism for 3-OST-3.
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{{ABSTRACT_PUBMED_15304505}}
==About this Structure==
==About this Structure==
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[[Category: Alpha-beta motif]]
[[Category: Alpha-beta motif]]
[[Category: Substrate-binding cleft]]
[[Category: Substrate-binding cleft]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:40:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:03:13 2008''

Revision as of 13:03, 27 July 2008

Image:1t8t.png

Template:STRUCTURE 1t8t

Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP

Template:ABSTRACT PUBMED 15304505

About this Structure

1T8T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1., Moon AF, Edavettal SC, Krahn JM, Munoz EM, Negishi M, Linhardt RJ, Liu J, Pedersen LC, J Biol Chem. 2004 Oct 22;279(43):45185-93. Epub 2004 Aug 10. PMID:15304505

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