1ta0

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[[Image:1ta0.gif|left|200px]]
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{{Seed}}
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[[Image:1ta0.png|left|200px]]
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{{STRUCTURE_1ta0| PDB=1ta0 | SCENE= }}
{{STRUCTURE_1ta0| PDB=1ta0 | SCENE= }}
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'''Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand.'''
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===Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand.===
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==Overview==
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Recycling of RNA polymerase II (Pol II) after transcription requires dephosphorylation of the polymerase C-terminal domain (CTD) by the phosphatase Fcp1. We report the X-ray structure of the small CTD phosphatase Scp1, which is homologous to the Fcp1 catalytic domain. The structure shows a core fold and an active center similar to those of phosphotransferases and phosphohydrolases that solely share a DXDX(V/T) signature motif with Fcp1/Scp1. We demonstrate that the first aspartate in the signature motif undergoes metal-assisted phosphorylation during catalysis, resulting in a phosphoaspartate intermediate that was structurally mimicked with the inhibitor beryllofluoride. Specificity may result from CTD binding to a conserved hydrophobic pocket between the active site and an insertion domain that is unique to Fcp1/Scp1. Fcp1 specificity may additionally arise from phosphatase recruitment near the CTD via the Pol II subcomplex Rpb4/7, which is shown to be required for binding of Fcp1 to the polymerase in vitro.
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The line below this paragraph, {{ABSTRACT_PUBMED_15304220}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15304220 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15304220}}
==About this Structure==
==About this Structure==
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[[Category: Meinhart, T.]]
[[Category: Meinhart, T.]]
[[Category: Alpha-beta protein]]
[[Category: Alpha-beta protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:43:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:52:24 2008''

Revision as of 07:52, 29 July 2008

Image:1ta0.png

Template:STRUCTURE 1ta0

Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand.

Template:ABSTRACT PUBMED 15304220

About this Structure

1TA0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of RNA polymerase II CTD phosphatases., Kamenski T, Heilmeier S, Meinhart A, Cramer P, Mol Cell. 2004 Aug 13;15(3):399-407. PMID:15304220

Page seeded by OCA on Tue Jul 29 10:52:24 2008

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