1tab

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{{STRUCTURE_1tab| PDB=1tab | SCENE= }}
{{STRUCTURE_1tab| PDB=1tab | SCENE= }}
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'''STRUCTURE OF THE TRYPSIN-BINDING DOMAIN OF BOWMAN-BIRK TYPE PROTEASE INHIBITOR AND ITS INTERACTION WITH TRYPSIN'''
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===STRUCTURE OF THE TRYPSIN-BINDING DOMAIN OF BOWMAN-BIRK TYPE PROTEASE INHIBITOR AND ITS INTERACTION WITH TRYPSIN===
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==Overview==
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The crystal structure of the complex formed by bovine trypsin and Bowman-Birk type protease inhibitor AB-I extracted from azuki beans (Vigna angularis) 'Takara' has been analyzed. The structure was solved by the application of the phase combination of single isomorphous phases and trypsin model phases, followed by phase improvement using the iterative Fourier technique. From the resulting electron density map, a three-dimensional atomic model of the trypsin binding domain of AB-I has been built. The peptide chain at the trypsin reactive site turns back sharply at Pro29 and forms a 9-residue ring (Cys24-Cys32). The 'front side' of this ring, consisting of the reactive site (Cys24-Met28), interacts with trypsin in a similar manner to other families of inhibitors and forms a stable complex, which seems to be maintained by the interactions with the 'back side' of this ring (Pro29-Cys34). The similar spatial arrangements of the 'back side' of this inhibitor and the 'secondary contact region' of the other inhibitors with respect to the reactive site suggest an important common role of these regions in exhibiting inhibitory activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 3032921 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3032921}}
==About this Structure==
==About this Structure==
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[[Category: Watanabe, K.]]
[[Category: Watanabe, K.]]
[[Category: Yamane, T.]]
[[Category: Yamane, T.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:25:07 2008''

Revision as of 16:25, 28 July 2008

Image:1tab.png

Template:STRUCTURE 1tab

STRUCTURE OF THE TRYPSIN-BINDING DOMAIN OF BOWMAN-BIRK TYPE PROTEASE INHIBITOR AND ITS INTERACTION WITH TRYPSIN

Template:ABSTRACT PUBMED 3032921

About this Structure

1TAB is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

Structure of the trypsin-binding domain of Bowman-Birk type protease inhibitor and its interaction with trypsin., Tsunogae Y, Tanaka I, Yamane T, Kikkawa J, Ashida T, Ishikawa C, Watanabe K, Nakamura S, Takahashi K, J Biochem. 1986 Dec;100(6):1637-46. PMID:3032921

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