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1tbd

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[[Image:1tbd.gif|left|200px]]
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[[Image:1tbd.png|left|200px]]
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==Overview==
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{{ABSTRACT_8946857}}
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The structure of the domain from simian virus 40 (SV40) large T-antigen that binds to the SV40 origin of DNA replication (T-ag-OBD131-260) has been determined by nuclear magnetic resonance spectroscopy. The overall fold, consisting of a central five-stranded antiparallel beta-sheet flanked by two alpha-helices on one side and one alpha-helix and one 3(10)-helix on the other, is a new one. Previous mutational analyses have identified two elements, termed A (approximately 152-155) and B2 (203-207), as essential for origin-specific recognition. These elements form two closely juxtaposed loops that define a continuous surface on the protein. The addition of a duplex oligonucleotide containing the origin recognition pentanucleotide GAGGC induces chemical shift changes and slows amide proton exchange in resonances from this region, indicating that this surface directly contacts the DNA.
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==About this Structure==
==About this Structure==
1TBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. The following page contains interesting information on the relation of 1TBD with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb47_1.html Simian Virus 40]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBD OCA].
1TBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. The following page contains interesting information on the relation of 1TBD with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb47_1.html Simian Virus 40]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBD OCA].
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==Reference==
 
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Solution structure of the origin DNA-binding domain of SV40 T-antigen., Luo X, Sanford DG, Bullock PA, Bachovchin WW, Nat Struct Biol. 1996 Dec;3(12):1034-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8946857 8946857]
 
[[Category: Simian Virus 40]]
[[Category: Simian Virus 40]]
[[Category: Simian virus 40]]
[[Category: Simian virus 40]]
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[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Replication origin binding domain]]
[[Category: Replication origin binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:45:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:59:48 2008''

Revision as of 14:59, 26 June 2008

Image:1tbd.png

Template:STRUCTURE 1tbd

SOLUTION STRUCTURE OF THE ORIGIN DNA BINDING DOMAIN OF SV40 T-ANTIGEN, NMR, MINIMIZED AVERAGE STRUCTURE


Template:ABSTRACT 8946857

About this Structure

1TBD is a Single protein structure of sequence from Simian virus 40. The following page contains interesting information on the relation of 1TBD with [Simian Virus 40]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:59:48 2008

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