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1tbe

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[[Image:1tbe.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1tbe| PDB=1tbe | SCENE= }}
{{STRUCTURE_1tbe| PDB=1tbe | SCENE= }}
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'''STRUCTURE OF TETRAUBIQUITIN SHOWS HOW MULTIUBIQUITIN CHAINS CAN BE FORMED'''
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===STRUCTURE OF TETRAUBIQUITIN SHOWS HOW MULTIUBIQUITIN CHAINS CAN BE FORMED===
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==Overview==
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Eukaryotic proteins are targeted for degradation by covalent ligation of multiubiquitin chains. In these multiubiquitin chains, successive ubiquitins are linked by an isopeptide bond involving the side chain of Lys48 and the carboxyl group of the C-terminus (Gly76). The crystal structure of a tetraubiquitin chain (Ub4) has been determined and refined at 2.4 A resolution. The molecule exhibits both translational and 2-fold rotational symmetry; each pair of (rotationally symmetric) ubiquitin molecules in Ub4 is related to the next pair by a simple translation. The 2-fold symmetry in each pair of ubiquitin molecules is quite different from the 2-fold symmetry observed in the previously determined structure of isolated diubiquitin. There are multiple hydrophilic contacts among the four ubiquitin molecules, but the hydrophobic surface formed in the middle of diubiquitin is not seen. The structure of the tetraubiquitin chain demonstrates how a multiubiquitin chain of any length can be formed.
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The line below this paragraph, {{ABSTRACT_PUBMED_8107144}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8107144 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8107144}}
==About this Structure==
==About this Structure==
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[[Category: Pickart, C M.]]
[[Category: Pickart, C M.]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:45:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:17:54 2008''

Revision as of 06:17, 28 July 2008

Image:1tbe.png

Template:STRUCTURE 1tbe

STRUCTURE OF TETRAUBIQUITIN SHOWS HOW MULTIUBIQUITIN CHAINS CAN BE FORMED

Template:ABSTRACT PUBMED 8107144

About this Structure

1TBE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of tetraubiquitin shows how multiubiquitin chains can be formed., Cook WJ, Jeffrey LC, Kasperek E, Pickart CM, J Mol Biol. 1994 Feb 18;236(2):601-9. PMID:8107144

Page seeded by OCA on Mon Jul 28 09:17:54 2008

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