9dgi
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cannabinoid receptor 1-Gi complex with novel ligand== | |
| - | + | <StructureSection load='9dgi' size='340' side='right'caption='[[9dgi]], [[Resolution|resolution]] 3.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9dgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DGI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YVF:methyl+(2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate'>YVF</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dgi OCA], [https://pdbe.org/9dgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dgi RCSB], [https://www.ebi.ac.uk/pdbsum/9dgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dgi ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Basbaum AI]] | ||
| + | [[Category: Braz JM]] | ||
| + | [[Category: Iliopoulos-Tsoutsouvas C]] | ||
| + | [[Category: Krishna Kumar K]] | ||
| + | [[Category: Makriyannis M]] | ||
| + | [[Category: O'Brien ES]] | ||
| + | [[Category: Shoichet BK]] | ||
| + | [[Category: Tummino TA]] | ||
Revision as of 10:32, 30 April 2025
Cannabinoid receptor 1-Gi complex with novel ligand
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