1tez

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[[Image:1tez.gif|left|200px]]
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{{STRUCTURE_1tez| PDB=1tez | SCENE= }}
{{STRUCTURE_1tez| PDB=1tez | SCENE= }}
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'''COMPLEX BETWEEN DNA AND THE DNA PHOTOLYASE FROM ANACYSTIS NIDULANS'''
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===COMPLEX BETWEEN DNA AND THE DNA PHOTOLYASE FROM ANACYSTIS NIDULANS===
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==Overview==
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DNA photolyases use light energy to repair DNA that comprises ultraviolet-induced lesions such as the cis-syn cyclobutane pyrimidine dimers (CPDs). Here we report the crystal structure of a DNA photolyase bound to duplex DNA that is bent by 50 degrees and comprises a synthetic CPD lesion. This CPD lesion is flipped into the active site and split there into two thymines by synchrotron radiation at 100 K. Although photolyases catalyze blue light-driven CPD cleavage only above 200 K, this structure apparently mimics a structural substate during light-driven DNA repair in which back-flipping of the thymines into duplex DNA has not yet taken place.
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(as it appears on PubMed at http://www.pubmed.gov), where 15576622 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15576622}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair., Mees A, Klar T, Gnau P, Hennecke U, Eker AP, Carell T, Essen LO, Science. 2004 Dec 3;306(5702):1789-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576622 15576622]
Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair., Mees A, Klar T, Gnau P, Hennecke U, Eker AP, Carell T, Essen LO, Science. 2004 Dec 3;306(5702):1789-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576622 15576622]
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Crystal structure of DNA photolyase from Anacystis nidulans., Tamada T, Kitadokoro K, Higuchi Y, Inaka K, Yasui A, de Ruiter PE, Eker AP, Miki K, Nat Struct Biol. 1997 Nov;4(11):887-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9360600 9360600]
[[Category: Deoxyribodipyrimidine photo-lyase]]
[[Category: Deoxyribodipyrimidine photo-lyase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Light-driven electron transfer]]
[[Category: Light-driven electron transfer]]
[[Category: Photolyase]]
[[Category: Photolyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:42:40 2008''

Revision as of 03:42, 29 July 2008

Image:1tez.png

Template:STRUCTURE 1tez

COMPLEX BETWEEN DNA AND THE DNA PHOTOLYASE FROM ANACYSTIS NIDULANS

Template:ABSTRACT PUBMED 15576622

About this Structure

1TEZ is a Single protein structure of sequence from Synechococcus sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair., Mees A, Klar T, Gnau P, Hennecke U, Eker AP, Carell T, Essen LO, Science. 2004 Dec 3;306(5702):1789-93. PMID:15576622

Crystal structure of DNA photolyase from Anacystis nidulans., Tamada T, Kitadokoro K, Higuchi Y, Inaka K, Yasui A, de Ruiter PE, Eker AP, Miki K, Nat Struct Biol. 1997 Nov;4(11):887-91. PMID:9360600

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