9diq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Apo-H5 hemagglutinin from the influenza virus A/37/Texas/2024 (H5N1)== | |
| - | + | <StructureSection load='9diq' size='340' side='right'caption='[[9diq]], [[Resolution|resolution]] 2.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9diq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DIQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9diq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9diq OCA], [https://pdbe.org/9diq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9diq RCSB], [https://www.ebi.ac.uk/pdbsum/9diq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9diq ProSAT]</span></td></tr> |
| - | [[Category: Wilson | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/A0A6B7HPT9_9INFA A0A6B7HPT9_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Influenza A virus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lin TH]] | ||
| + | [[Category: Wilson IA]] | ||
| + | [[Category: Zhu Y]] | ||
Current revision
Crystal structure of Apo-H5 hemagglutinin from the influenza virus A/37/Texas/2024 (H5N1)
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