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1th1

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[[Image:1th1.gif|left|200px]]
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{{STRUCTURE_1th1| PDB=1th1 | SCENE= }}
{{STRUCTURE_1th1| PDB=1th1 | SCENE= }}
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'''Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment'''
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===Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment===
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==Overview==
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The tumor suppressor adenomatous polyposis coli (APC) plays a critical role in the turnover of cytosolic beta-catenin, the key effector of the canonical Wnt signaling pathway. APC contains seven 20 amino acid (20 aa) beta-catenin binding repeats that are required for beta-catenin turnover. We have determined the crystal structure of beta-catenin in complex with a phosphorylated APC fragment containing two 20 aa repeats. Surprisingly, one single phosphorylated 20 aa repeat, together with its flanking regions, covers the entire structural groove of beta-catenin and may thus compete for beta-catenin binding with all other beta-catenin armadillo repeat partners. Our biochemical studies show that phosphorylation of the APC 20 aa repeats increases the affinity of the repeats for beta-catenin by 300- to 500-fold and the phosphorylated 20 aa repeats prevent beta-catenin binding to Tcf. Our work suggests that the phosphorylation of the APC 20 aa repeats could be a critical switch for APC function.
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(as it appears on PubMed at http://www.pubmed.gov), where 15327769 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15327769}}
==About this Structure==
==About this Structure==
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[[Category: Xu, W.]]
[[Category: Xu, W.]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:56:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:11:02 2008''

Revision as of 11:11, 27 July 2008

Image:1th1.png

Template:STRUCTURE 1th1

Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment

Template:ABSTRACT PUBMED 15327769

About this Structure

1TH1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function., Xing Y, Clements WK, Le Trong I, Hinds TR, Stenkamp R, Kimelman D, Xu W, Mol Cell. 2004 Aug 27;15(4):523-33. PMID:15327769

Page seeded by OCA on Sun Jul 27 14:11:02 2008

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