1tjf

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{{STRUCTURE_1tjf| PDB=1tjf | SCENE= }}
{{STRUCTURE_1tjf| PDB=1tjf | SCENE= }}
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'''The crystal structure of the N-terminal domain of CAP indicates variable oligomerisation'''
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===The crystal structure of the N-terminal domain of CAP indicates variable oligomerisation===
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==Overview==
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Cyclase-associated protein (CAP) is a highly conserved and widely distributed protein that links the nutritional response signaling to cytoskeleton remodeling. In yeast, CAP is a component of the adenylyl cyclase complex and helps to activate the Ras-mediated catalytic cycle of the cyclase. While the N-terminal domain of CAP (N-CAP) provides a binding site for adenylyl cyclase, the C-terminal domain (C-CAP) possesses actin binding activity. Our attempts to crystallize full-length recombinant CAP from Dictyostelium discoideum resulted in growth of orthorhombic crystals containing only the N-terminal domain (residues 42-227) due to auto-proteolytic cleavage. The structure was solved by molecular replacement with data at 2.2 A resolution. The present crystal structure allows the characterization of a head-to-tail N-CAP dimer in the asymmetric unit and a crystallographic side-to-side dimer. Comparison with previously published structures of N-CAP reveals variable modes of dimerization of this domain, but the presence of a common interface for the side-to-side dimer.
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{{ABSTRACT_PUBMED_15558566}}
==About this Structure==
==About this Structure==
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[[Category: Yusof, A Mohd.]]
[[Category: Yusof, A Mohd.]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:01:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:50:05 2008''

Revision as of 17:50, 27 July 2008

Image:1tjf.png

Template:STRUCTURE 1tjf

The crystal structure of the N-terminal domain of CAP indicates variable oligomerisation

Template:ABSTRACT PUBMED 15558566

About this Structure

1TJF is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP)., Yusof AM, Hu NJ, Wlodawer A, Hofmann A, Proteins. 2005 Feb 1;58(2):255-62. PMID:15558566

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