1tkv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1tkv.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1tkv.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1tkv| PDB=1tkv | SCENE= }}
{{STRUCTURE_1tkv| PDB=1tkv | SCENE= }}
-
'''Solution Structure of T4 AsiA Dimer'''
+
===Solution Structure of T4 AsiA Dimer===
-
==Overview==
+
<!--
-
The bacteriophage T4 AsiA protein is a multifunctional protein that simultaneously acts as both a repressor and activator of gene expression during the phage life cycle. These dual roles with opposing transcriptional consequences are achieved by modification of the host RNA polymerase in which AsiA binds to conserved region 4 (SR4) of sigma(70), altering the pathway of promoter selection by the holoenzyme. The mechanism by which AsiA flips this genetic switch has now been revealed, in part, from the three-dimensional structure of AsiA and the elucidation of its interaction with SR4. The structure of AsiA is that of a novel homodimer in which each monomer is constructed as a seven-helix bundle arranged in four overlapping helix-loop-helix elements. Identification of the protein interfaces for both the AsiA homodimer and the AsiA-sigma(70) complex reveals that these interfaces are coincident. Thus, the AsiA interaction with sigma(70) necessitates that the AsiA homodimer dissociate to form an AsiA-SR4 heterodimer, exchanging one protein subunit for another to alter promoter choice by RNA polymerase.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11742991}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11742991 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11742991}}
==About this Structure==
==About this Structure==
-
1TKV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ka3 1ka3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKV OCA].
+
1TKV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ka3 1ka3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKV OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Anti-sigma]]
[[Category: Anti-sigma]]
[[Category: Homodimer]]
[[Category: Homodimer]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:04:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:43:22 2008''

Revision as of 02:43, 28 July 2008

Image:1tkv.png

Template:STRUCTURE 1tkv

Solution Structure of T4 AsiA Dimer

Template:ABSTRACT PUBMED 11742991

About this Structure

1TKV is a Single protein structure of sequence from Enterobacteria phage t4. This structure supersedes the now removed PDB entry 1ka3. Full experimental information is available from OCA.

Reference

Flipping a genetic switch by subunit exchange., Lambert LJ, Schirf V, Demeler B, Cadene M, Werner MH, EMBO J. 2001 Dec 17;20(24):7149-59. PMID:11742991

Page seeded by OCA on Mon Jul 28 05:43:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tkv"
Personal tools