1tl2

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{{STRUCTURE_1tl2| PDB=1tl2 | SCENE= }}
{{STRUCTURE_1tl2| PDB=1tl2 | SCENE= }}
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'''TACHYLECTIN-2 FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB)'''
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===TACHYLECTIN-2 FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB)===
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==Overview==
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Tachylectin-2, isolated from large granules of the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus), is a 236 amino acid protein belonging to the lectins. It binds specifically to N-acetylglucosamine and N-acetylgalactosamine and is a part of the innate immunity host defense system of the horseshoe crab. The X-ray structure of tachylectin-2 was solved at 2.0 A resolution by the multiple isomorphous replacement method and this molecular model was employed to solve the X-ray structure of the complex with N-acetylglucosamine. Tachylectin-2 is the first protein displaying a five-bladed beta-propeller structure. Five four-stranded antiparallel beta-sheets of W-like topology are arranged around a central water-filled tunnel, with the water molecules arranged as a pentagonal dodecahedron. Tachylectin-2 exhibits five virtually identical binding sites, one in each beta-sheet. The binding sites are located between adjacent beta-sheets and are made by a large loop between the outermost strands of the beta-sheets and the connecting segment from the previous beta-sheet. The high number of five binding sites within the single polypeptide chain strongly suggests the recognition of carbohydrate surface structures of pathogens with a fairly high ligand density. Thus, tachylectin-2 employs strict specificity for certain N-acetyl sugars as well as the surface ligand density for self/non-self recognition.
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==About this Structure==
==About this Structure==
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[[Category: Horseshoe crab]]
[[Category: Horseshoe crab]]
[[Category: N-acetylglucosamine]]
[[Category: N-acetylglucosamine]]
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Revision as of 03:38, 28 July 2008

Image:1tl2.png

Template:STRUCTURE 1tl2

TACHYLECTIN-2 FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB)

Template:ABSTRACT PUBMED 10228146

About this Structure

1TL2 is a Single protein structure of sequence from Tachypleus tridentatus. Full crystallographic information is available from OCA.

Reference

Tachylectin-2: crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus., Beisel HG, Kawabata S, Iwanaga S, Huber R, Bode W, EMBO J. 1999 May 4;18(9):2313-22. PMID:10228146

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