1tlh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1tlh.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1tlh.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1tlh| PDB=1tlh | SCENE= }}
{{STRUCTURE_1tlh| PDB=1tlh | SCENE= }}
-
'''T4 AsiA bound to sigma70 region 4'''
+
===T4 AsiA bound to sigma70 region 4===
-
==Overview==
+
<!--
-
Bacteriophage T4 AsiA is a versatile transcription factor capable of inhibiting host gene expression as an 'anti-sigma' factor while simultaneously promoting gene-specific expression of T4 middle genes in conjunction with T4 MotA. To accomplish this task, AsiA engages conserved region 4 of Eschericia coli sigma70, blocking recognition of most host promoters by sequestering the DNA-binding surface at the AsiA/sigma70 interface. The three-dimensional structure of an AsiA/region 4 complex reveals that the C-terminal alpha helix of region 4 is unstructured, while four other helices adopt a completely different conformation relative to the canonical structure of unbound region 4. That AsiA induces, rather than merely stabilizes, this rearrangement can be realized by comparison to the homologous structures of region 4 solved in a variety of contexts, including the structure of Thermotoga maritima sigmaA region 4 described herein. AsiA simultaneously occupies the surface of region 4 that ordinarily contacts core RNA polymerase (RNAP), suggesting that an AsiA-bound sigma70 may also undergo conformational changes in the context of the RNAP holoenzyme.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15257291}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15257291 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15257291}}
==About this Structure==
==About this Structure==
-
1TLH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLH OCA].
+
1TLH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLH OCA].
==Reference==
==Reference==
Line 32: Line 36:
[[Category: Rna polymerase]]
[[Category: Rna polymerase]]
[[Category: Sigma70]]
[[Category: Sigma70]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:05:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:25:07 2008''

Revision as of 06:25, 28 July 2008

Image:1tlh.png

Template:STRUCTURE 1tlh

T4 AsiA bound to sigma70 region 4

Template:ABSTRACT PUBMED 15257291

About this Structure

1TLH is a Protein complex structure of sequences from Enterobacteria phage t4 and Escherichia coli. Full experimental information is available from OCA.

Reference

T4 AsiA blocks DNA recognition by remodeling sigma70 region 4., Lambert LJ, Wei Y, Schirf V, Demeler B, Werner MH, EMBO J. 2004 Aug 4;23(15):2952-62. Epub 2004 Jul 15. PMID:15257291

Page seeded by OCA on Mon Jul 28 09:25:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tlh"
Personal tools