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1tn9

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[[Image:1tn9.gif|left|200px]]
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{{STRUCTURE_1tn9| PDB=1tn9 | SCENE= }}
{{STRUCTURE_1tn9| PDB=1tn9 | SCENE= }}
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'''THE SOLUTION STRUCTURE OF TN916 INTEGRASE N-TERMINAL DOMAIN/DNA COMPLEX'''
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===THE SOLUTION STRUCTURE OF TN916 INTEGRASE N-TERMINAL DOMAIN/DNA COMPLEX===
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==Overview==
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The integrase protein catalyzes the excision and integration of the Tn916 conjugative transposon, a promiscuous genetic element that spreads antibiotic resistance in pathogenic bacteria. The solution structure of the N-terminal domain of the Tn916 integrase protein bound to its DNA-binding site within the transposon arm has been determined. The structure reveals an interesting mode of DNA recognition, in which the face of a three-stranded antiparallel beta-sheet is positioned within the major groove. A comparison to the structure of the homing endonuclease I-Ppol-DNA complex suggests that the three-stranded sheet may represent a new DNA-binding motif whose residue composition and position within the major groove are varied to alter specificity. The structure also provides insights into the mechanism of conjugative transposition. The DNA in the complex is bent approximately 35 degrees and may, together with potential interactions between bound integrase proteins at directly repeated sites, significantly bend the arms of the transposon.
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(as it appears on PubMed at http://www.pubmed.gov), where 10201406 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10201406}}
==About this Structure==
==About this Structure==
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1TN9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TN9 OCA].
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1TN9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TN9 OCA].
==Reference==
==Reference==
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[[Category: Integrase]]
[[Category: Integrase]]
[[Category: Transposition]]
[[Category: Transposition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:09:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:23:29 2008''

Revision as of 02:23, 29 July 2008

Image:1tn9.png

Template:STRUCTURE 1tn9

THE SOLUTION STRUCTURE OF TN916 INTEGRASE N-TERMINAL DOMAIN/DNA COMPLEX

Template:ABSTRACT PUBMED 10201406

About this Structure

1TN9 is a Single protein structure of sequence from Enterococcus faecalis. Full experimental information is available from OCA.

Reference

NMR structure of the Tn916 integrase-DNA complex., Wojciak JM, Connolly KM, Clubb RT, Nat Struct Biol. 1999 Apr;6(4):366-73. PMID:10201406

Page seeded by OCA on Tue Jul 29 05:23:29 2008

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