9dod
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of PRMT5:MEP50 in complex with PRT543== | |
| - | + | <StructureSection load='9dod' size='340' side='right'caption='[[9dod]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9dod]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DOD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A79:(2~{R},3~{S},4~{R},5~{R})-5-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)-2-[(~{R})-(3,4-dichlorophenyl)-oxidanyl-methyl]-3-methyl-oxolane-3,4-diol'>A1A79</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dod OCA], [https://pdbe.org/9dod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dod RCSB], [https://www.ebi.ac.uk/pdbsum/9dod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dod ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MEP50_HUMAN MEP50_HUMAN] Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.<ref>PMID:11756452</ref> <ref>PMID:23071334</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dou Y]] | ||
| + | [[Category: Leal RA]] | ||
| + | [[Category: Lin H]] | ||
| + | [[Category: Pitis PM]] | ||
| + | [[Category: Wang M]] | ||
| + | [[Category: Xu C]] | ||
Current revision
Crystal structure of PRMT5:MEP50 in complex with PRT543
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Categories: Homo sapiens | Large Structures | Dou Y | Leal RA | Lin H | Pitis PM | Wang M | Xu C
