1tou

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[[Image:1tou.gif|left|200px]]
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{{STRUCTURE_1tou| PDB=1tou | SCENE= }}
{{STRUCTURE_1tou| PDB=1tou | SCENE= }}
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'''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand'''
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===Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand===
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==Overview==
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The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.
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(as it appears on PubMed at http://www.pubmed.gov), where 15357970 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15357970}}
==About this Structure==
==About this Structure==
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[[Category: Lipid-binding]]
[[Category: Lipid-binding]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:12:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:18:18 2008''

Revision as of 02:18, 28 July 2008

Image:1tou.png

Template:STRUCTURE 1tou

Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand

Template:ABSTRACT PUBMED 15357970

About this Structure

1TOU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970

Page seeded by OCA on Mon Jul 28 05:18:18 2008

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