1tow

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[[Image:1tow.gif|left|200px]]
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{{Seed}}
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[[Image:1tow.png|left|200px]]
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{{STRUCTURE_1tow| PDB=1tow | SCENE= }}
{{STRUCTURE_1tow| PDB=1tow | SCENE= }}
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'''Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand'''
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===Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand===
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==Overview==
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Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.
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The line below this paragraph, {{ABSTRACT_PUBMED_15357969}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15357969 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15357969}}
==About this Structure==
==About this Structure==
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[[Category: Lipid-binding]]
[[Category: Lipid-binding]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:12:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:01:37 2008''

Revision as of 16:01, 28 July 2008

Image:1tow.png

Template:STRUCTURE 1tow

Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand

Template:ABSTRACT PUBMED 15357969

About this Structure

1TOW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:15357969

Page seeded by OCA on Mon Jul 28 19:01:37 2008

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