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1tpg

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[[Image:1tpg.gif|left|200px]]
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{{Seed}}
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[[Image:1tpg.png|left|200px]]
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{{STRUCTURE_1tpg| PDB=1tpg | SCENE= }}
{{STRUCTURE_1tpg| PDB=1tpg | SCENE= }}
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'''F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)'''
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===F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)===
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==Overview==
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BACKGROUND: The thrombolytic serine protease tissue-type plasminogen activator (t-PA) is a classical modular protein consisting of three types of domain in addition to the serine protease domain: F1 (homologous to fibronectin type I); G (epidermal growth factor-like) and kringle. Biochemical data suggest that the F1 and G modules play a major role in the binding of t-PA to fibrin and to receptors on hepatocytes. RESULTS: We have derived the solution structure of the F1 and G pair of modules from t-PA by two- and three-dimensional NMR techniques, in combination with dynamical simulated annealing calculations. We have also obtained information about the molecule's backbone dynamics through measurement of amide 15N relaxation parameters. CONCLUSIONS: Although the F1 and G modules each adopt their expected tertiary structure, the modules interact intimately to bury a hydrophobic core, and the inter-module linker makes up the third strand of the G module's major beta-sheet. The new structural results allow the interpretation of earlier mutational data relevant to fibrin-binding and hepatocyte-receptor binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_7582899}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7582899 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7582899}}
==About this Structure==
==About this Structure==
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1TPG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPG OCA].
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1TPG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPG OCA].
==Reference==
==Reference==
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[[Category: Smith, B O.]]
[[Category: Smith, B O.]]
[[Category: Plasminogen activation]]
[[Category: Plasminogen activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:13:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:46:08 2008''

Revision as of 03:46, 28 July 2008

Image:1tpg.png

Template:STRUCTURE 1tpg

F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)

Template:ABSTRACT PUBMED 7582899

About this Structure

1TPG is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator., Smith BO, Downing AK, Driscoll PC, Dudgeon TJ, Campbell ID, Structure. 1995 Aug 15;3(8):823-33. PMID:7582899

Page seeded by OCA on Mon Jul 28 06:46:08 2008

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