This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1tq4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1tq4.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1tq4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1tq4| PDB=1tq4 | SCENE= }}
{{STRUCTURE_1tq4| PDB=1tq4 | SCENE= }}
-
'''Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases'''
+
===Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases===
-
==Overview==
+
<!--
-
Interferon-inducible p47 GTPases are critical mediators of cell-autonomous resistance against several intracellular pathogens. Here we present the first crystal structure of a member of this novel GTPase family, IIGP1, in its nucleotide-free, GDP-, and GppNHp-bound form. The structure shows a Ras-like G domain between an N-terminal three-helix bundle and a complex system of C-terminal helices and loops. Sequence comparison and secondary structure prediction suggest the IIGP1 structure to be a valid model for the p47 GTPase family. The IIGP1 crystals contain a noncrystallographic dimer. We show that the dimer is required for cooperative GTP hydrolysis and GTP-dependent oligomerization of IIGP1. We also present the GDP- and GppNHp-bound monomeric structures of two dimer interface mutants. Our structures direct approaches to the analysis of the catalytic mechanism of IIGP1 and provide a coherent basis for structure-function studies aimed at elucidating the mechanistic basis of pathogen resistance caused by these enigmatic GTPases.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15350217}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15350217 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15350217}}
==About this Structure==
==About this Structure==
Line 20: Line 24:
==Reference==
==Reference==
Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases., Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E, Mol Cell. 2004 Sep 10;15(5):727-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15350217 15350217]
Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases., Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E, Mol Cell. 2004 Sep 10;15(5):727-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15350217 15350217]
 +
 +
IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization., Uthaiah RC, Praefcke GJ, Howard JC, Herrmann C, J Biol Chem. 2003 Aug 1;278(31):29336-43. Epub 2003 May 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12732635 12732635]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 32: Line 38:
[[Category: Immunology]]
[[Category: Immunology]]
[[Category: Interferon gamma]]
[[Category: Interferon gamma]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:14:36 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:18:54 2008''

Revision as of 17:18, 28 July 2008

Image:1tq4.png

Template:STRUCTURE 1tq4

Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases

Template:ABSTRACT PUBMED 15350217

About this Structure

1TQ4 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases., Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E, Mol Cell. 2004 Sep 10;15(5):727-39. PMID:15350217

IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization., Uthaiah RC, Praefcke GJ, Howard JC, Herrmann C, J Biol Chem. 2003 Aug 1;278(31):29336-43. Epub 2003 May 5. PMID:12732635

Page seeded by OCA on Mon Jul 28 20:18:54 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tq4"
Personal tools