1ts2

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{{STRUCTURE_1ts2| PDB=1ts2 | SCENE= }}
{{STRUCTURE_1ts2| PDB=1ts2 | SCENE= }}
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'''T128A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS'''
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===T128A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS===
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==Overview==
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The three-dimensional structures of five mutants of toxic shock syndrome toxin-1 (TSST-1) have been determined. These mutations are in the long central alpha helix and are useful in mapping portions of TSST-1 involved in superantigenicity and lethality. The T128A, H135A, Q139K, and I140T mutations appear to reduce superantigenicity by altering the properties of the T-cell receptor interaction surface. The Q136A mutation is at a largely buried site and causes a dramatic change in the conformation of the beta7-beta9 loop which covers the back of the central alpha helix. As this mutation has the unique ability to reduce the toxin's lethality in rabbits while retaining its superantigenicity, it raises the possibility that this rear loop mediates the ability of TSST-1 to induce lethality and suggests a route for producing nonlethal toxins for therapeutic development.
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(as it appears on PubMed at http://www.pubmed.gov), where 9585531 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9585531}}
==About this Structure==
==About this Structure==
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[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:18:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:34:23 2008''

Revision as of 17:34, 28 July 2008

Image:1ts2.png

Template:STRUCTURE 1ts2

T128A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS

Template:ABSTRACT PUBMED 9585531

About this Structure

1TS2 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity., Earhart CA, Mitchell DT, Murray DL, Pinheiro DM, Matsumura M, Schlievert PM, Ohlendorf DH, Biochemistry. 1998 May 19;37(20):7194-202. PMID:9585531

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