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1tt9

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[[Image:1tt9.gif|left|200px]]
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{{STRUCTURE_1tt9| PDB=1tt9 | SCENE= }}
{{STRUCTURE_1tt9| PDB=1tt9 | SCENE= }}
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'''Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer'''
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===Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer===
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==Overview==
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Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton. It is also linked to two human diseases, autoimmune hepatitis and glutamate formiminotransferase deficiency. Determination of the FTCD structure by X-ray crystallography and electron cryomicroscopy revealed that the eight subunits, each composed of distinct FT and CD domains, are arranged like a square doughnut. A key finding indicates that coupling of three subunits governs the octamer-dependent sequential enzyme activities, including channeling of intermediate and conformational change. The structure further shed light on the molecular nature of two strong antigenic determinants of FTCD recognized by autoantibodies from patients with autoimmune hepatitis and on the binding of thin vimentin filaments to the FTCD octamer.
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(as it appears on PubMed at http://www.pubmed.gov), where 15272307 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15272307}}
==About this Structure==
==About this Structure==
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[[Category: Structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:20:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:00:01 2008''

Revision as of 12:00, 28 July 2008

Image:1tt9.png

Template:STRUCTURE 1tt9

Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer

Template:ABSTRACT PUBMED 15272307

About this Structure

1TT9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer., Mao Y, Vyas NK, Vyas MN, Chen DH, Ludtke SJ, Chiu W, Quiocho FA, EMBO J. 2004 Aug 4;23(15):2963-71. Epub 2004 Jul 22. PMID:15272307

Page seeded by OCA on Mon Jul 28 15:00:01 2008

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