1tup

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[[Image:1tup.gif|left|200px]]
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[[Image:1tup.png|left|200px]]
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==Overview==
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{{ABSTRACT_8023157}}
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Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations in human cancer. The majority of the mutations occur in the core domain which contains the sequence-specific DNA binding activity of the p53 protein (residues 102-292), and they result in loss of DNA binding. The crystal structure of a complex containing the core domain of human p53 and a DNA binding site has been determined at 2.2 angstroms resolution and refined to a crystallographic R factor of 20.5 percent. The core domain structure consists of a beta sandwich that serves as a scaffold for two large loops and a loop-sheet-helix motif. The two loops, which are held together in part by a tetrahedrally coordinated zinc atom, and the loop-sheet-helix motif form the DNA binding surface of p53. Residues from the loop-sheet-helix motif interact in the major groove of the DNA, while an arginine from one of the two large loops interacts in the minor groove. The loops and the loop-sheet-helix motif consist of the conserved regions of the core domain and contain the majority of the p53 mutations identified in tumors. The structure supports the hypothesis that DNA binding is critical for the biological activity of p53, and provides a framework for understanding how mutations inactivate it.
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==About this Structure==
==About this Structure==
1TUP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TUP with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb31_1.html p53 Tumor Suppressor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUP OCA].
1TUP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TUP with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb31_1.html p53 Tumor Suppressor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUP OCA].
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==Reference==
 
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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations., Cho Y, Gorina S, Jeffrey PD, Pavletich NP, Science. 1994 Jul 15;265(5170):346-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8023157 8023157]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Pavletich, N P.]]
[[Category: Pavletich, N P.]]
[[Category: Antigen p53]]
[[Category: Antigen p53]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:23:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:02:28 2008''

Revision as of 15:02, 26 June 2008

Image:1tup.png

Template:STRUCTURE 1tup

TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA


Template:ABSTRACT 8023157

About this Structure

1TUP is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1TUP with [p53 Tumor Suppressor]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:02:28 2008

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