1tvc

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[[Image:1tvc.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1tvc| PDB=1tvc | SCENE= }}
{{STRUCTURE_1tvc| PDB=1tvc | SCENE= }}
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'''FAD and NADH binding domain of methane monooxygenase reductase from Methylococcus capsulatus (Bath)'''
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===FAD and NADH binding domain of methane monooxygenase reductase from Methylococcus capsulatus (Bath)===
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==Overview==
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Soluble methane monooxygenase (sMMO) catalyzes the hydroxylation of methane by dioxygen to methanol, the first step in carbon assimilation by methanotrophs. This multicomponent system transfers electrons from NADH through a reductase component to the non-heme diiron center in the hydroxylase where O(2) is activated. The reductase component comprises three distinct domains, a [2Fe-2S] ferredoxin domain along with FAD- and NADH-binding domains. We report the solution structure of the reduced 27.6 kDa FAD- and NADH-binding domains (MMOR-FAD) of the reductase from Methylococcus capsulatus (Bath). The FAD-binding domain consists of a six-stranded antiparallel beta-barrel and one alpha-helix, with the first 10 N-terminal residues unstructured. In the interface between the two domains, the FAD cofactor is tightly bound in an unprecedented extended conformation. The NADH-binding domain consists of a five-stranded parallel beta-sheet with four alpha-helices packing closely around this sheet. MMOR-FAD is structurally homologous to other FAD-containing oxidoreductases, and we expect similar structures for the FAD/NADH-binding domains of reductases that occur in other multicomponent monooxygenases.
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(as it appears on PubMed at http://www.pubmed.gov), where 15379538 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15379538}}
==About this Structure==
==About this Structure==
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1TVC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVC OCA].
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1TVC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVC OCA].
==Reference==
==Reference==
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[[Category: Fad-binding]]
[[Category: Fad-binding]]
[[Category: Nadh-binding]]
[[Category: Nadh-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:24:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:18:50 2008''

Revision as of 12:18, 27 July 2008

Image:1tvc.png

Template:STRUCTURE 1tvc

FAD and NADH binding domain of methane monooxygenase reductase from Methylococcus capsulatus (Bath)

Template:ABSTRACT PUBMED 15379538

About this Structure

1TVC is a Single protein structure of sequence from Methylococcus capsulatus. Full experimental information is available from OCA.

Reference

NMR structure of the flavin domain from soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath)., Chatwood LL, Muller J, Gross JD, Wagner G, Lippard SJ, Biochemistry. 2004 Sep 28;43(38):11983-91. PMID:15379538

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