1twi

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{{STRUCTURE_1twi| PDB=1twi | SCENE= }}
{{STRUCTURE_1twi| PDB=1twi | SCENE= }}
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'''Crystal structure of Diaminopimelate Decarboxylase from m. jannaschii in co-complex with L-lysine'''
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===Crystal structure of Diaminopimelate Decarboxylase from m. jannaschii in co-complex with L-lysine===
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==Overview==
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Cocrystal structures of Methanococcus jannaschii diaminopimelate decarboxylase (DAPDC) bound to a substrate analog, azelaic acid, and its L-lysine product have been determined at 2.6 A and 2.0 A, respectively. This PLP-dependent enzyme is responsible for the final step of L-lysine biosynthesis in bacteria and plays a role in beta-lactam antibiotic resistance in Staphylococcus aureus. Substrate specificity derives from recognition of the L-chiral center of diaminopimelate and a system of ionic "molecular rulers" that dictate substrate length. A coupled-enzyme assay system permitted measurement of kinetic parameters for recombinant DAPDCs and inhibition constants (K(i)) for azelaic acid (89 microM) and other substrate analogs. Implications for rational design of broad-spectrum antimicrobial agents targeted against DAPDCs of drug-resistant strains of bacterial pathogens, such as Staphylococcus aureus, are discussed.
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{{ABSTRACT_PUBMED_12429091}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: T135]]
[[Category: T135]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:27:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:38:01 2008''

Revision as of 11:38, 29 July 2008

Image:1twi.png

Template:STRUCTURE 1twi

Crystal structure of Diaminopimelate Decarboxylase from m. jannaschii in co-complex with L-lysine

Template:ABSTRACT PUBMED 12429091

About this Structure

1TWI is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor., Ray SS, Bonanno JB, Rajashankar KR, Pinho MG, He G, De Lencastre H, Tomasz A, Burley SK, Structure. 2002 Nov;10(11):1499-508. PMID:12429091

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