1tx8

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{{STRUCTURE_1tx8| PDB=1tx8 | SCENE= }}
{{STRUCTURE_1tx8| PDB=1tx8 | SCENE= }}
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'''Bovine Trypsin complexed with AMSO'''
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===Bovine Trypsin complexed with AMSO===
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==Overview==
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We have designed, synthesized, and evaluated the factor Xa inhibitory activities of p-amidinophenyl-sulfones, amines, and alcohols intended to take advantage of the polarity and hydrogen-bonding potential of the oxyanion hole region of the S1 specificity pocket. We demonstrate that placement of an anionic group within the oxyanion hole region of the catalytic site substantially enhances activity, with small flexible groups favored over bulkier ones. Ab initio pKa calculations suggest that the hydroxyl substituent frequently used for benzamidine moieties may be ionized to form an anionic group, consistent with the general trend. One nonamidine based substituent also shows promising activity.
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{{ABSTRACT_PUBMED_15380220}}
==About this Structure==
==About this Structure==
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[[Category: Mesecar, A D.]]
[[Category: Mesecar, A D.]]
[[Category: Trypsin]]
[[Category: Trypsin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:28:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:49:41 2008''

Revision as of 17:49, 28 July 2008

Image:1tx8.png

Template:STRUCTURE 1tx8

Bovine Trypsin complexed with AMSO

Template:ABSTRACT PUBMED 15380220

About this Structure

1TX8 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa., Rumthao S, Lee O, Sheng Q, Fu W, Mulhearn DC, Crich D, Mesecar AD, Johnson ME, Bioorg Med Chem Lett. 2004 Oct 18;14(20):5165-70. PMID:15380220

Page seeded by OCA on Mon Jul 28 20:49:41 2008

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