1xh3
From Proteopedia
(New page: 200px<br /> <applet load="1xh3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xh3, resolution 1.48Å" /> '''Conformational Rest...) |
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caption="1xh3, resolution 1.48Å" /> | caption="1xh3, resolution 1.48Å" /> | ||
'''Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501'''<br /> | '''Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XH3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1XH3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XH3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: immune system]] | [[Category: immune system]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:09:17 2008'' |
Revision as of 15:09, 15 February 2008
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Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501
Contents |
Overview
Human HLA-B*3501 binds an antigenic peptide of 14-aa length derived from, an alternative reading frame of M-CSF with high affinity. Due to its, extraordinary length, the exact HLA binding mode was unpredictable. The, crystal structure of HLA-B*3501 at 1.5 A shows that the N and C termini of, the peptide are embedded in the A and F pockets, respectively, similar to, a peptide of normal length. The central part of the 14-meric peptide, bulges flexibly out of the groove. Two variants of the alternative reading, frame of M-CSF peptide substituted at P2 or P2 and P9 with Ala display, weak or no T cell activation. Their structure differs mainly in, flexibility and conformation from the agonistic peptide. Moreover, the, variants induce subtle changes of MHC alpha-helical regions implicated as, critical for TCR contact. The TCR specifically recognizing this, peptide/MHC complex exhibits CDR3 length within the normal range, suggesting major conformational adaptations of this receptor upon, peptide/MHC binding. Thus, the potential antigenic repertoire recognizable, by CTLs is larger than currently thought.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142830], Hypoproteinemia, hypercatabolic OMIM:[109700], Spondyloarthropathy, susceptibility to, 1 OMIM:[142830], Stevens-Johnson syndrome, carbamazepine-induced, susceptibility to OMIM:[142830]
About this Structure
1XH3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Conformational restraints and flexibility of 14-meric peptides in complex with HLA-B*3501., Probst-Kepper M, Hecht HJ, Herrmann H, Janke V, Ocklenburg F, Klempnauer J, van den Eynde BJ, Weiss S, J Immunol. 2004 Nov 1;173(9):5610-6. PMID:15494511
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