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1ty4

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[[Image:1ty4.gif|left|200px]]
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{{STRUCTURE_1ty4| PDB=1ty4 | SCENE= }}
{{STRUCTURE_1ty4| PDB=1ty4 | SCENE= }}
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'''Crystal structure of a CED-9/EGL-1 complex'''
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===Crystal structure of a CED-9/EGL-1 complex===
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==Overview==
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Programmed cell death in Caenorhabditis elegans is initiated by the binding of EGL-1 to CED-9, which disrupts the CED-4/CED-9 complex and allows CED-4 to activate the cell-killing caspase CED-3. Here we demonstrate that the C-terminal half of EGL-1 is necessary and sufficient for binding to CED-9 and for killing cells. Structure of the EGL-1/CED-9 complex revealed that EGL-1 adopts an extended alpha-helical conformation and induces substantial structural rearrangements in CED-9 upon binding. EGL-1 interface mutants failed to bind to CED-9 or to release CED-4 from the CED-4/CED-9 complex, and were unable to induce cell death in vivo. A surface patch on CED-9, different from that required for binding to EGL-1, was identified to be responsible for binding to CED-4. These data suggest a working mechanism for the release of CED-4 from the CED-4/CED-9 complex upon EGL-1 binding and provide a mechanistic framework for understanding apoptosis activation in C. elegans.
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The line below this paragraph, {{ABSTRACT_PUBMED_15383288}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15383288 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15383288}}
==About this Structure==
==About this Structure==
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[[Category: Egl-1]]
[[Category: Egl-1]]
[[Category: Recognition]]
[[Category: Recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:30:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:05:40 2008''

Revision as of 21:05, 27 July 2008

Image:1ty4.png

Template:STRUCTURE 1ty4

Crystal structure of a CED-9/EGL-1 complex

Template:ABSTRACT PUBMED 15383288

About this Structure

1TY4 is a Protein complex structure of sequences from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4., Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y, Mol Cell. 2004 Sep 24;15(6):999-1006. PMID:15383288

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