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1tzd

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{{STRUCTURE_1tzd| PDB=1tzd | SCENE= }}
{{STRUCTURE_1tzd| PDB=1tzd | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE'''
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===CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE===
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==Overview==
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Soluble inositol polyphosphates are ubiquitous second messengers in eukaryotes, and their levels are regulated by an array of specialized kinases. The structure of an archetypal member of this class, inositol 1,4,5-trisphosphate 3-kinase (IP3K), has been determined at 2.2 angstroms resolution in complex with magnesium and adenosine diphosphate. IP3K contains a catalytic domain that is a variant of the protein kinase superfamily, and a novel four-helix substrate binding domain. The two domains are in an open conformation with respect to each other, suggesting that substrate recognition and catalysis by IP3K involves a dynamic conformational cycle. The unique helical domain of IP3K blocks access to the active site by membrane-bound phosphoinositides, explaining the structural basis for soluble inositol polyphosphate specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_15350215}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15350215 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15350215}}
==About this Structure==
==About this Structure==
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[[Category: Miller, G J.]]
[[Category: Miller, G J.]]
[[Category: Inositol kinase]]
[[Category: Inositol kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:33:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:25:51 2008''

Revision as of 14:25, 28 July 2008

Image:1tzd.png

Template:STRUCTURE 1tzd

CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE

Template:ABSTRACT PUBMED 15350215

About this Structure

1TZD is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase., Miller GJ, Hurley JH, Mol Cell. 2004 Sep 10;15(5):703-11. PMID:15350215

Page seeded by OCA on Mon Jul 28 17:25:51 2008

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