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1tzl

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{{STRUCTURE_1tzl| PDB=1tzl | SCENE= }}
{{STRUCTURE_1tzl| PDB=1tzl | SCENE= }}
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'''Crystal Structure of Pyranose 2-Oxidase from the White-Rot Fungus Peniophora sp.'''
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===Crystal Structure of Pyranose 2-Oxidase from the White-Rot Fungus Peniophora sp.===
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==Overview==
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Pyranose 2-oxidase catalyzes the oxidation of a number of carbohydrates using dioxygen. The enzyme forms a D(2) symmetric homotetramer and contains one covalently bound FAD per subunit. The structure of the enzyme from Peniophora sp. was determined by multiwavelength anomalous diffraction (MAD) based on 96 selenium sites per crystallographic asymmetric unit and subsequently refined to good-quality indices. According to its chain fold, the enzyme belongs to the large glutathione reductase family and, in a more narrow sense, to the glucose-methanol-choline oxidoreductase (GMC) family. The tetramer contains a spacious central cavity from which the substrate enters one of the four active centers by penetrating a mobile barrier. Since this cavity can only be accessed by glucose-sized molecules, the enzyme does not convert sugars that are part of a larger molecule. The geometry of the active center and a comparison with an inhibitor complex of the homologous enzyme cellobiose dehydrogenase allow the modeling of the reaction at a high confidence level.
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{{ABSTRACT_PUBMED_15362852}}
==About this Structure==
==About this Structure==
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[[Category: Gmc oxidoreductase]]
[[Category: Gmc oxidoreductase]]
[[Category: Large inner cavity]]
[[Category: Large inner cavity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:33:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:44:00 2008''

Revision as of 07:44, 28 July 2008

Image:1tzl.png

Template:STRUCTURE 1tzl

Crystal Structure of Pyranose 2-Oxidase from the White-Rot Fungus Peniophora sp.

Template:ABSTRACT PUBMED 15362852

About this Structure

1TZL is a Single protein structure of sequence from Peniophora sp. sg. Full crystallographic information is available from OCA.

Reference

Crystal structure of pyranose 2-oxidase from the white-rot fungus Peniophora sp., Bannwarth M, Bastian S, Heckmann-Pohl D, Giffhorn F, Schulz GE, Biochemistry. 2004 Sep 21;43(37):11683-90. PMID:15362852

Page seeded by OCA on Mon Jul 28 10:44:00 2008

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