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1tzy

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{{STRUCTURE_1tzy| PDB=1tzy | SCENE= }}
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'''Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution'''
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===Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution===
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==Overview==
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Crystals of native histone octamers (H2A-H2B)-(H4-H3)-(H3'-H4')-(H2B'-H2A') from chick erythrocytes in 2 M KCl, 1.35 M potassium phosphate pH 6.9 diffract X-rays to 1.90 A resolution, yielding a structure with an R(work) value of 18.7% and an Rfree of 22.2%. The crystal space group is P6(5), the asymmetric unit of which contains one complete octamer. This high-resolution model of the histone-core octamer allows further insight into intermolecular interactions, including water molecules, that dock the histone dimers to the tetramer in the nucleosome-core particle and have relevance to nucleosome remodelling. The three key areas analysed are the H2A'-H3-H4 molecular cluster (also H2A-H3'-H4'), the H4-H2B' interaction (also H4'-H2B) and the H2A'-H4 beta-sheet interaction (also H2A-H4'). The latter of these three regions is important to nucleosome remodelling by RNA polymerase II, as it is shown to be a likely core-histone binding site, and its disruption creates an instability in the nucleosome-core particle. A majority of the water molecules in the high-resolution octamer have positions that correlate to similar positions in the high-resolution nucleosome-core particle structure, suggesting that the high-resolution octamer model can be used for comparative studies with the high-resolution nucleosome-core particle.
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{{ABSTRACT_PUBMED_16511091}}
==About this Structure==
==About this Structure==
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[[Category: Histone-fold]]
[[Category: Histone-fold]]
[[Category: Tetramer-dimer-dimer]]
[[Category: Tetramer-dimer-dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:42:07 2008''

Revision as of 23:42, 27 July 2008

Image:1tzy.png

Template:STRUCTURE 1tzy

Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution

Template:ABSTRACT PUBMED 16511091

About this Structure

1TZY is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

High-resolution structure of the native histone octamer., Wood CM, Nicholson JM, Lambert SJ, Chantalat L, Reynolds CD, Baldwin JP, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt, 6):541-5. Epub 2005 Jun 1. PMID:16511091

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