9e6h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Maackia amurensis seed Leukoagglutinin (lectin), MASL== | |
| - | + | <StructureSection load='9e6h' size='340' side='right'caption='[[9e6h]], [[Resolution|resolution]] 2.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9e6h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Maackia_amurensis Maackia amurensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9E6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9E6H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.84Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9e6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9e6h OCA], [https://pdbe.org/9e6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9e6h RCSB], [https://www.ebi.ac.uk/pdbsum/9e6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9e6h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MALS_MAAAM MALS_MAAAM] Sialic acid-binding lectin recognizing oligosaccharides containing terminal sialic acid linked via alpha-2,3 bond to penultimate galactose residues (PubMed:3350806). Binds the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,4-GlcNAc (PubMed:1985926). Binds fetuin when fully glycosylated but not when the high mannose-type glycans are removed, although the secondary structure is virtually unaffected by deglycosylation of the high mannose-type glycans (PubMed:26003537). The lectin activity may depend on the presence of a single GlcNAc attached to N-90 (PubMed:26003537).<ref>PMID:1985926</ref> <ref>PMID:26003537</ref> <ref>PMID:3350806</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Maackia amurensis]] | ||
| + | [[Category: Goldberg GS]] | ||
| + | [[Category: Nayak AR]] | ||
| + | [[Category: Temiakov D]] | ||
Current revision
Cryo-EM structure of Maackia amurensis seed Leukoagglutinin (lectin), MASL
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