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1u3c

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{{STRUCTURE_1u3c| PDB=1u3c | SCENE= }}
{{STRUCTURE_1u3c| PDB=1u3c | SCENE= }}
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'''Crystal Structure of the PHR domain of Cryptochrome 1 from Arabidopsis thaliana'''
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===Crystal Structure of the PHR domain of Cryptochrome 1 from Arabidopsis thaliana===
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==Overview==
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Signals generated by cryptochrome (CRY) blue-light photoreceptors are responsible for a variety of developmental and circadian responses in plants. The CRYs are also identified as circadian blue-light photoreceptors in Drosophila and components of the mammalian circadian clock. These flavoproteins all have an N-terminal domain that is similar to photolyase, and most have an additional C-terminal domain of variable length. We present here the crystal structure of the photolyase-like domain of CRY-1 from Arabidopsis thaliana. The structure reveals a fold that is very similar to photolyase, with a single molecule of FAD noncovalently bound to the protein. The surface features of the protein and the dissimilarity of a surface cavity to that of photolyase account for its lack of DNA-repair activity. Previous in vitro experiments established that the photolyase-like domain of CRY-1 can bind Mg.ATP, and we observe a single molecule of an ATP analog bound in the aforementioned surface cavity, near the bound FAD cofactor. The structure has implications for the signaling mechanism of CRY blue-light photoreceptors.
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{{ABSTRACT_PUBMED_15299148}}
==About this Structure==
==About this Structure==
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[[Category: Amppnp]]
[[Category: Amppnp]]
[[Category: Photolyase]]
[[Category: Photolyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:42:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:22:07 2008''

Revision as of 02:22, 29 July 2008

Image:1u3c.png

Template:STRUCTURE 1u3c

Crystal Structure of the PHR domain of Cryptochrome 1 from Arabidopsis thaliana

Template:ABSTRACT PUBMED 15299148

About this Structure

1U3C is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana., Brautigam CA, Smith BS, Ma Z, Palnitkar M, Tomchick DR, Machius M, Deisenhofer J, Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12142-7. Epub 2004 Aug 6. PMID:15299148

Page seeded by OCA on Tue Jul 29 05:22:07 2008

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