1u4h

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{{STRUCTURE_1u4h| PDB=1u4h | SCENE= }}
{{STRUCTURE_1u4h| PDB=1u4h | SCENE= }}
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'''Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)'''
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===Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)===
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==Overview==
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Soluble guanylate cyclases are nitric oxide-responsive signaling proteins in which the nitric oxide sensor is a heme-binding domain of unknown structure that we have termed the heme-NO and oxygen binding (H-NOX) domain. H-NOX domains are also found in bacteria, either as isolated domains, or are fused through a membrane-spanning region to methyl-accepting chemotaxis proteins. We have determined the crystal structure of an oxygen-binding H-NOX domain of one such signaling protein from the obligate anaerobe Thermoanaerobacter tengcongensis at 1.77-angstroms resolution, revealing a protein fold unrelated to known structures. Particularly striking is the structure of the protoporphyrin IX group, which is distorted from planarity to an extent not seen before in protein-bound heme groups. Comparison of the structure of the H-NOX domain in two different crystal forms suggests a mechanism whereby alteration in the degree of distortion of the heme group is coupled to changes on the molecular surface of the H-NOX domain and potentially to changes in intermolecular interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15326296 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15326296}}
==About this Structure==
==About this Structure==
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[[Category: Oxygen sensor]]
[[Category: Oxygen sensor]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:45:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:57:49 2008''

Revision as of 00:57, 28 July 2008

Image:1u4h.png

Template:STRUCTURE 1u4h

Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)

Template:ABSTRACT PUBMED 15326296

About this Structure

1U4H is a Single protein structure of sequence from Thermoanaerobacter tengcongensis. Full crystallographic information is available from OCA.

Reference

Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases., Pellicena P, Karow DS, Boon EM, Marletta MA, Kuriyan J, Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9. Epub 2004 Aug 23. PMID:15326296

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