1u5u

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[[Image:1u5u.gif|left|200px]]
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{{Seed}}
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[[Image:1u5u.png|left|200px]]
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{{STRUCTURE_1u5u| PDB=1u5u | SCENE= }}
{{STRUCTURE_1u5u| PDB=1u5u | SCENE= }}
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'''The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold'''
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===The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold===
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==Overview==
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8R-Lipoxygenase and allene oxide synthase (AOS) are parts of a naturally occurring fusion protein from the coral Plexaura homomalla. AOS catalyses the production of an unstable epoxide (an allene oxide) from the fatty acid hydroperoxide generated by the lipoxygenase activity. Here, we report the structure of the AOS domain and its striking structural homology to catalase. Whereas nominal sequence identity between the enzymes had been previously described, the extent of structural homology observed was not anticipated, given that this enzyme activity had been exclusively associated with the P450 superfamily, and conservation of a catalase fold without catalase activity is unprecedented. Whereas the heme environment is largely conserved, the AOS heme is planar and the distal histidine is flanked by two hydrogen-bonding residues. These critical differences likely facilitate the switch from a catalatic activity to that of a fatty acid hydroperoxidase.
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(as it appears on PubMed at http://www.pubmed.gov), where 15625113 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15625113}}
==About this Structure==
==About this Structure==
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[[Category: Fusion protein]]
[[Category: Fusion protein]]
[[Category: Heme]]
[[Category: Heme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:47:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:12:38 2008''

Revision as of 09:12, 29 July 2008

Image:1u5u.png

Template:STRUCTURE 1u5u

The structure of an Allene Oxide Synthase reveals a novel use for a catalase fold

Template:ABSTRACT PUBMED 15625113

About this Structure

1U5U is a Single protein structure of sequence from Plexaura homomalla. Full crystallographic information is available from OCA.

Reference

The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide., Oldham ML, Brash AR, Newcomer ME, Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):297-302. Epub 2004 Dec 29. PMID:15625113

Page seeded by OCA on Tue Jul 29 12:12:38 2008

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